Tailored immunity at mucosae

The Mucosae-Associated Epithelial Chemokine (MEC/CCL28) Modulates Immunity in HIV Infection

BACKGROUND CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propria (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse m...

Mucosae, allergy and probiotics.

Muscularis mucosae - the forgotten sibling.

Lamina muscularis mucosae sitting beneath mucosal surface of the digestive tract has received little attention to date compared with external smooth muscle layers. Motor activity of the muscularis mucosae shows a great regional and species difference. Autonomic innervation profile is also different from esophagus to colon or between animal species. Intracellular transduction mechanisms for moto...

Tailored e-learning modules at the BBC

Given its reputation for innovative broadcast communications, it is not surprising that the BBC has adopted a considered approach to e-learning. This case study concentrates on the production of an online course on 'Editorial Policy' and demonstrates their comprehensive approach to e-learning. However those involved in e-learning at the BBC emphasise that they have developed their thinking over...

Cellular Immunity at Birth

Immunity in the infant has been extensively studied in the past and numerous investigations have been made into the development of specific immunity, the production of antibody and the passive transfer of antibody from the mother. On the other hand comparatively little work has been devoted to elucidating the complexities of the cellular response since Tunnicliff (1910) observed that phagocytos...